What is it about?

Pancreatic cancer is a highly lethal malignancy. However, over the past few decades, therapeutic drugs for pancreatic cancer have yielded very limited success in clinical trials. Signal Transducer and Activator of Transcription-3 (STAT3) is a pro-oncogenic transcription factor. Natural products serve as an inexhaustible source of anticancer drugs. We identified the natural product trienomycin A (TA), an ansamycin antibiotic, as a potential inhibitor of the STAT3 pathway with potent activity against pancreatic cancer.

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Why is it important?

Pancreatic cancer is an exceptionally fatal disease. However, therapeutic drugs for pancreatic cancer have presented a serious shortage over the past few decades.

Perspectives

Currently, there is a lack of effective therapeutic drugs for pancreatic cancer patients. According to our preliminary study, trienomycin A can be a new potential candidate compound for treating pancreatic cancer, and it is valuable to be further investigated.

Qiu-Rui He
College of Chemistry & Pharmacy, Northwest A&F University

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This page is a summary of: The natural product trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer, British Journal of Pharmacology, April 2021, Wiley, DOI: 10.1111/bph.15435.
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