What is it about?
We have found that two nicotinic receptor subtypes alpha 7 and alpha 9 present in carcinoma cell lines can modulate cell proliferation and we have investigated the possible intracellular pathways.
Featured Image
Why is it important?
We think that the two receptors can be suitable targets for a new pharmacological approach to limit lung tumoral cell proliferation through specific receptor antagonists, RNA silencers or other biological drugs
Perspectives
Neuronal nicotinic receptors that are present in several peripheral tissues and in seven tumors could be a novel target to address that could be useful to limit the pathological dangers provoked by smoking
Francesco Clementi
University of Milano, CNR institute of Neuroscience
Read the Original
This page is a summary of: α9- and α7-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line, Bone Marrow Transplantation, September 2017, Wiley,
DOI: 10.1111/bph.13954.
You can read the full text:
Contributors
The following have contributed to this page
