Inhibition of matrix metalloproteinase‐9 by a barbiturate‐nitrate hybrid ameliorates dextran sulphate sodium‐induced colitis: effect on inflammation‐related genes

What is it about?

Inflammatory bowel disease is a chronic inflammatory condition where matrix metalloproteinase-9 plays a vital role. We have designed a new barbiturate-based MMP inhibitor incorporating a nitric oxide donor/mimetic group drugs that prevents inflammation in experimental models of coliits in rats. This novel drug therefore may emerge as a promising anti-inflammatory approach in inflammatory bowel disease.

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