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What is it about?
This study examined the impact of kidney stone disease (KSD) and its treatment on the health-related quality of life (HRQOL) of high-risk stone formers with hyperparathyroidism, renal tubular acidosis, malabsorptive disease, and medullary sponge kidney. The Wisconsin Stone Quality of Life questionnaire was used to evaluate HRQOL in 3301 patients with a history of KSD from 16 institutions in North America between 2014 and 2020. The high-risk group had significantly lower HRQOL scores compared to the control group. Medullary sponge kidney disease and renal tubular acidosis were independent predictors of poorer HRQOL, while alkali therapy was an independent predictor of better HRQOL. Clinicians should seek to identify these patients earlier as they would benefit from prompt treatment and prevention.
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Why is it important?
This research is important as it provides valuable insights into the impact of kidney stone disease (KSD) and its treatment on the health-related quality of life (HRQOL) of high-risk stone formers with specific medical conditions. It highlights the impaired HRQOL experienced by these patients, emphasizing the need for early identification and prompt treatment to improve their overall quality of life. Key Takeaways: 1. High-risk stone formers with KSD, particularly those having medullary sponge kidney disease and renal tubular acidosis, have significantly lower HRQOL compared to the general population. 2. Alkali therapy was found to be an independent predictor of better HRQOL in patients with active KSD. 3. Early identification of high-risk stone formers and prompt treatment and prevention strategies can improve the overall quality of life for these patients.
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This page is a summary of: The impact of kidney stone disease on quality of life in high‐risk stone formers, BJU International, February 2024, Wiley,
DOI: 10.1111/bju.16294.
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