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What is it about?
This study examines the morphometric variations of Cajal-like cells (CLCs) in children with primary pelviureteric junction obstruction (PUJO). A reduced CLC density was associated with PUJO, and CLC distribution patterns were found to be different in cases and controls. The study used immunohistochemistry and image segmentation to determine the morphometric characteristics of CLCs and found that cases exhibited a clustered pattern of distribution, while controls showed a more homogeneous pattern. The study also found that CLCs of patients with PUJO showed greater Feret's diameter and solidity, indicating cellular dysfunctions that could be reflected in cytomorphometric changes. The study received no specific grants from any funding agency in the public, commercial or not-for-profit sector.
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Why is it important?
This research is important as it sheds light on the potential role of morphometric variations of Cajal-like cells (CLCs) in the pathogenesis of primary pelviureteric junction obstruction (PUJO) in children. By using immunohistochemistry coupled with an image segmentation approach, the study provides new insights into the associations between CLC density, distribution, and primary PUJO. This information could help in the development of diagnostic and therapeutic strategies for managing PUJO in children. Key Takeaways: 1. The study investigates the relationship between Cajal-like cells (CLCs) and primary pelviureteric junction obstruction (PUJO) in children. 2. The research uses immunohistochemistry and image segmentation to analyze CLC density and distribution in patients with PUJO and controls. 3. The study finds no significant difference in CLC density between cases and controls but identifies a distinct distributional variation of CLCs in patients with PUJO. 4. The findings suggest that the morphometric characteristics of CLCs may be linked to the pathogenesis of PUJO.
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This page is a summary of: Morphometric variations of Cajal‐like cells are associated with pelviureteric junction obstruction in children, BJU International, July 2023, Wiley,
DOI: 10.1111/bju.16107.
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