Long-Term Voiding and Renal Function After Radical Cystectomy and Orthotopic Neobladder in Women

What is it about?

The article discusses the long-term functional outcomes of radical cystectomy (RC) and orthotopic neobladder (ONB) reconstruction in women. It evaluates the long-term voiding and renal function changes after RC and ONB surgery in women without disease recurrence. Among the 195 patients included in the study, 95 had >10 years of follow-up. The study found that while daytime continence and night-time continence were maintained, chronic urine retention (CUR) increased over time. Additionally, RF deterioration occurred in 74 patients throughout the follow-up and chronic kidney disease (CKD) stage III-V developed in 80 patients. The study concludes that while women with RC and ONB maintained acceptable continence status, RF deterioration developed in nearly half of them after 10 years of follow-up.

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Why is it important?

This research is important because it provides valuable information on the long-term outcomes of radical cystectomy and orthotopic neobladder surgery in women, specifically in relation to voiding and renal function. Understanding the long-term effects of these procedures can help healthcare professionals make more informed decisions regarding patient care and management. Key Takeaways: 1. Women who underwent radical cystectomy and orthotopic neobladder reconstruction between 1995 and 2011 were included in the study. 2. Long-term voiding function and the incidence and predictors of renal function deterioration were assessed. 3. Among patients with >10 years of follow-up, 82% had daytime continence, 66% had night-time continence, and 33% had chronic urine retention. 4. Renal function deterioration events occurred in 74 patients throughout the follow-up and chronic kidney disease stage III-V developed in 80 patients. 5. Patients' age and serous-lined extramural tunnel diversion were identified as independent predictors of renal function deterioration.