Genetic predisposition, lifestyle, and bladder cancer risk

What is it about?

The study examined the association between polygenic risk score (PRS) and bladder cancer (BC) risk and whether a healthy lifestyle can offset this risk. It was found that there was a negative interaction between PRS and healthy lifestyle score (HLS) and that a healthy lifestyle can reduce BC risk. Individuals with high genetic risk and unfavorable lifestyle had increased BC risk compared to those with low genetic risk and favorable lifestyle. The study concluded that their findings provide important evidence to support tailoring lifestyle recommendations to an individual's genetic makeup for BC prevention.

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Why is it important?

The research is important because it investigates the association between polygenic risk score (PRS) and bladder cancer (BC) risk and whether a healthy lifestyle can offset the genetic predisposition to BC. This study highlights the importance of considering both genetic and lifestyle factors in understanding the risk of developing BC. Key Takeaways: 1. A negative interaction was observed between the PRS and the healthy lifestyle score (HLS) in individuals with BC. 2. A 7% higher and 28% lower BC risk per 1-standard deviation (SD) increment in PRS and HLS were observed, respectively. 3. Adherence to a healthy lifestyle reduced the risk of BC and offset the effect of genetics. 4. Individuals with a high genetic risk and an unfavourable lifestyle had an increased BC risk compared to individuals with a low genetic risk and a favourable lifestyle. 5. The study highlights the importance of considering both genetic and lifestyle factors in understanding the risk of developing BC.