What is it about?

To evaluate the efficacy and safety of tramadol in patients with idiopathic detrusor overactivity (IDO).

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Why is it important?

The International Continence Society has updated the terminology of the symptoms, signs, urodynamic observations and conditions associated with lower urinary tract dysfunction. Overactive bladder (OAB) is one with inappropriate and involuntary contractions, causing urgency, frequency and/or urinary incontinence. It has an overall prevalence of 16% in Western Europe and 17% in the USA. Idiopathic detrusor overactivity (IDO) is defined as detrusor overactivity with no known precipitating cause.


Tramadol was effective and well tolerated in treating IDO. These promising results should motivate the development of further double-blind, placebo-controlled trials including more patients and a longterm study to confirm our findings and determine the acceptability of this treatment over a longer follow-up.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

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This page is a summary of: Retraction statement: Safety and efficacy of tramadol in the treatment of idiopathic detrusor overactivity: A double-blind, placebo-controlled, randomized study, British Journal of Clinical Pharmacology, December 2013, Wiley,
DOI: 10.1111/bcp.12304.
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