Fertility preservation of cancer patients by spermatogonial stem cell transplantation
What is it about?
SSC transplantation has been proposed as a promising technique to preserve the fertility of these patients. In mice, this technique has resulted in live‐born offspring, but the efficiency of colonization remained low. This could be because of a deficient microenvironment, leading to apoptosis of the transplanted SSCs. Interestingly, mesenchymal stem cells (MSCs), being multipotent and easy to isolate and multiply in vitro, are nowadays successfully and widely used in regenerative medicine.
Why is it important?
Improved treatments have led to an increased survival rate in cancer patients. However, in pre‐pubertal boys, these gonadotoxic treatments can result in the depletion of the spermatogonial stem cell (SSC) pool causing lifelong infertility.
The following have contributed to this page: Dr Prashant H Kadam
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