Association between genetic polymorphisms involved in the hypoxia-inducible factor pathway and lung cancer risk: a case-control study in Japan

  • Association between genetic polymorphisms
  • Yuzo Yamamoto, Chikako Kiyohara, Saiko Ogata-Suetsugu, Naoki Hamada, Yoichi Nakanishi
  • Asia-Pacific Journal of Clinical Oncology, December 2016, Wiley
  • DOI: 10.1111/ajco.12640

Genetic polymorphisms involved in the hypoxia-inducible factor pathway and lung cancer risk

What is it about?

Hypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and genetic polymorphisms involved in the HIF pathway.

Why is it important?

Hypoxia-inducible factor 2A rs13419896 and vascular endothelial growth factor A rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking.

Perspectives

Chikako KIyohara

Findings from polymorphism-environment interaction analyses must be interpreted with caution because of limited numbers of observations in the subgroups. Therefore, replication of the studies with a large number of cases and controls is required to confirm our findings.

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http://dx.doi.org/10.1111/ajco.12640

The following have contributed to this page: Chikako KIyohara

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