The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice

Cara L. Green, Sharon E. Mitchell, Davina Derous, Yingchun Wang, Luonan Chen, Jing-Dong J. Han, Daniel E. L. Promislow, David Lusseau, Alex Douglas, John R. Speakman
  • Aging Cell, January 2017, Wiley
  • DOI: 10.1111/acel.12570

What is it about?

Calorie restriction has been shown to extend lifespan and health span in several species. Here, we look at short-term calorie restriction in mice, to try and determine 1) if short-term calorie restriction is enough to cause changes and 2) if the beneficial effects caused by calorie restriction are due to changes in liver metabolism.

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The following have contributed to this page: Dr Cara L Green, ms Davina Derous, Professor John Speakman, and Daniel Promislow