What is it about?
The manuscript deals with the prothrombotic state in Behçet’s disease and it’s association of the P-Selectin Glycoprotein Ligand-1 (PSGL-1) gene polymorphism, which has been found to be associated with an increased risk of thrombosis in patients with antiphospholipid syndrome.
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Why is it important?
There is no data in the literature about the difference in the distribution of the heterozygosity for PSGL-1 gene exon 2 variable number of tandem repeat polymorphism in Behçet’s disease patients with thrombosis compared to those patients without any thrombotic event. In the present study, we observed a difference in the distribution of the heterozygosity for PSGL-1 VNTR polymorphism in BD patients with thrombosis compared to those patients without any thrombotic event.
Perspectives
I should state that writing this article was very challenging and satisfactory in scientific manner. I hope that our article leads to inspirations for new researches in clarification on the pathogenesis of thrombotic complications of the Behçet's disease to the readers.
Ozgun Gedar Totuk
Bahcesehir Universitesi
Read the Original
This page is a summary of: The association between P selectin glycoprotein ligand 1 gene variable number of tandem repeats polymorphism and risk of thrombosis in Behçet's disease, International Journal of Rheumatic Diseases, August 2017, Wiley,
DOI: 10.1111/1756-185x.13151.
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