Increased expression of CSP and CYP genes in adult silkworm females exposed to avermectins

Ning Xuan, Xia Guo, Hong-Yan Xie, Qi-Nian Lou, Xing-Bo Lu, Guo-Xia Liu, Jean-François Picimbon
  • Insect Science, April 2014, Wiley
  • DOI: 10.1111/1744-7917.12116

Role of Chemosensory Proteins (CSPs) in insecticide resistance

What is it about?

We analyzed expression of the 20 Bombyx mori CSP genes across all various tissues of the insect body. We thus tested the effects of insecticide abamectin on BmorCSP gene expression. A single brief exposure to insecticide increased dramatically CSP expression mainly in the gut and fat body (COVER PAGE)

Why is it important?

Our work shows that CSPs play no role in olfaction. The function of CSPs is reset. We showed coordinate expression of CSPs and metabolic cytochrome P450 enzymes in a tissue-dependent manner in response to the insecticide. We suggest a role in transporting xenobiotics that are then detoxified by cytochrome P450 anti-xenobiotic enzymes.


Prof. Dr. Jean-François Jeff Picimbon (Author)
Qilu University of Technology

CSPs as a whole protein family should be renamed.

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The following have contributed to this page: Prof. Dr. Jean-François Jeff Picimbon