What is it about?
By using the guidelines that this article recommends, authors publishing structural biology studies using small-angle scattering (SAXS or SANS) will ensure their readers understand the quality of their data and the validity of models presented. The paper provides explanation for the relevance of the recommended guidelines as well as examples data sets and modelling approaches.
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Why is it important?
Small-angle scattering is increasingly popular for structure biology studies. The technique can provide structural information that is both accurate and precise and, especially when used in combination with complementary data, of considerable value for studying individual molecules, complexes and assemblies. However, without stringent attention to data and model validation, there is significant potential for over-interpretation or even being misled. Adherence to the publication guidelines will give the experimenter, the reviewer and reader confidence in results.
Perspectives
This paper was a collaboration among 22 leaders in small-angle scattering and structural biology from around the world, and it was a pleasure to work with outstanding team on a project that we hope will ensure small angle scattering will play its role in driving forward the field of structural biology.
Prof. Jill Trewhella
University of Sydney
Read the Original
This page is a summary of: 2017 publication guidelines for structural modelling of small-angle scattering data from biomolecules in solution: an update, Acta Crystallographica Section D Structural Biology, August 2017, International Union of Crystallography,
DOI: 10.1107/s2059798317011597.
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