What is it about?
We benchmarked cryoSPARC helical reconstruction on deposited and in-house amyloid cryo-EM datasets, tested current capabilities, identified key limitations, and present comprehensive user guidelines for optimized amyloid processing workflows.
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Why is it important?
Effective software development relies on community involvement and feedback. To expand cryoSPARC into a truly universal processing pipeline capable of handling both single-particle analysis and helical reconstruction, comprehensive guidelines for reconstructing amyloids need to be established and formalized.
Perspectives
Our goal is to shift the focus of amyloid cryo-EM from computationally intensive processing challenges towards addressing fundamental biological questions that enhance our capacity for treatment discovery.
Jan Hannes Schaefer
Scripps Research Institute
Read the Original
This page is a summary of: Helical reconstruction of amyloids in
cryoSPARC, Acta Crystallographica Section F Structural Biology Communications, June 2026, International Union of Crystallography,
DOI: 10.1107/s2053230x26003675.
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