Cloning, expression, purification, crystallization and preliminary crystallographic analysis of the C-terminal domain of Par-4 (PAWR)

What is it about?

Par-4 is a pro-apoptotic protein with tumor suppressor activity. It can selectively induce apoptosis in cancer cells. It contains two important functional domains: N-terminal SAC domain, which is a minimum possible region that can induce apoptosis selectively and C-terminal coiled-coil domain which is a regulatory domain. This presented work is regarding the C-terminal regulatory domain.

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