What is it about?
The paper describes high-throughput (HTP) encapsulated nanodroplet crystallization (ENaCt) method and the X-ray structure of of a benzamide bearing 4-aminoantipyrine. The benzamide was synthesized following standard amide synthesis protocols. The goal was Ru-catalyzed C-H bond arylation with aryl bromides that we reported to be successful.
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Why is it important?
The high-throughput (HTP) encapsulated nanodroplet crystallization (ENaCt) performed on the 2-methylbenzamide bearing 4-aminoantipyrine paved the way for X-ray structure determination. The X-ray structure provided conclusive evidence for the benzamide structure. Therefore, laying ground for conclusive confirmation of regioselectivity/site-selectivity of the successful Ru-catalyzed ortho-C-H bond arylation.
Perspectives
This work is crucial towards conclusive confirmation of regioselectivity/site-selectivity of the successful Ru-catalyzed ortho-C-H bond arylation that we reported recently. Conclusive determination of the regioselectivity of C-H bond functionalization is of critical importance. In particular, the work is critical towards determination of the directing ability of 4-aminoantipyrine as a bidentate directing group in C-H bond functiolization.
Hamad Al Mamari
Sultan Qaboos University
Read the Original
This page is a summary of: High-throughput crystallization and crystal structure of N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-methylbenzamide: a benzamide bearing the 4-aminoantipyrine moiety, Acta Crystallographica Section C Structural Chemistry, November 2024, International Union of Crystallography,
DOI: 10.1107/s2053229624010982.
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