What is it about?
We used a simple synthesis to make four compounds, derived from indole and salicylaldehyde. They have been fully characterized, including 1H and 13C NMR spectroscopy. For two of the compounds, X-ray crystal structures are reported and discussed.
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Why is it important?
Closely related compounds have been used for cancer chemotherapy agents, cytodifferentiation, analgesis, anti-inflammation, radio-imaging contrast, colorimetric sensing, metal analyte preconcentration, and metal ligation for catalysis. Also, the X-ray structures of these compounds show an interesting hydrogen bonding pattern.
Perspectives
Many students over many years contributed different small pieces of data to this publication. Although our research has shifted focus since this project was initiated, it was fun to be able to share their work.
Yutan Getzler
Kenyon College
Read the Original
This page is a summary of: Synthesis and crystal structures of some bis(3-methyl-1H-indol-2-yl)(salicyl)methanes, Acta Crystallographica Section C Structural Chemistry, January 2019, International Union of Crystallography,
DOI: 10.1107/s2053229618017758.
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Contributors
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