What is it about?
We have synthesized five new Pt(II) complexes of type trans-[PtCl2(AlkEug)(Qui)], (2) and (3), and [PtCl(amine)(AlkEug)], (4)-(6) with high yields (≥ 89%) and determined their structures by means of IR, ESI-MS and XRD methods. The results of testing in vitro cytotoxicity against KB, LU, Hep-G2 and MCF-7 cancer cell lines of (2)-(6) indicate that the excellent cytotoxicity (the IC50 values of 0.38-29.23 μM) indeed depends on the amine ligand and increases in the order: quinoline-2-carboxylate complex (6) < quinoline complexes (2) and (3) < quinoline-8-olate complexes (4) and (5). The IC50 values of the most promising complex (5) are at least 30 times lower than that of cisplatin.
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Why is it important?
Our findings indicate the significant in vitro cytotoxicity of five new Pt(II) complexes against four human cancer cell lines and the unambiguous influence of the amine ligand on the cytotoxicity. This warrants further research the potential applications of the complexes in pharmaceutical.
Perspectives
It was my great pleasure to write this paper with the co-authors whom I have had long-standing collaborations. As our lab has insufficient equipment for further study on potential applications of the complexes in pharmaceutical. I hope this article leads researchers on anticancer activities contacting me to perform this work together.
chi Nguyen Thi Thanh
Hanoi National University of Education
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This page is a summary of: Mixed natural arylolefin–quinoline platinum(II) complexes: synthesis, structural characterization and in vitro cytotoxicity studies, Acta Crystallographica Section C Structural Chemistry, November 2018, International Union of Crystallography,
DOI: 10.1107/s2053229618015978.
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