What is it about?
This paper summarize different cases of of formation salts and co-crystals of amino acids with maleic acid. In all these cases formation of C22(12) crystallographic motif was found. Here we explain why it forms and calculate energies of all intermolecular interactions in the crystal of L-valinium hydrogen maleate
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Why is it important?
Topic is interesting due to formation of different salts and co-crystals from initial compounds with very different solubility. This is not common for salts and co-crystals of small organic molecules. Finally the question of why maleic acid, but not other always favour mixed crystals and one motif is always forms. The question of thermodynamics and kinetics controll is rised and answered
Perspectives
NLO properties could be measured for this system with respect to other maleates of amino acids. Maleic acid might be studied more carefully with respect to formation of mixed crystals with pharmaceutical substances with low solubility
Dr Denis A. Rychkov
Novosibirsk State University, ISSC SB RAS
Read the Original
This page is a summary of: Structure-forming units of amino acid maleates. Case study ofL-valinium hydrogen maleate, Acta Crystallographica Section B Structural Science Crystal Engineering and Materials, January 2016, International Union of Crystallography,
DOI: 10.1107/s2052520615021022.
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Resources
New hydrophobic L -amino acid salts: maleates of L -leucine, L -isoleucinNew hydrophobic L -amino acid salts: maleates of L -leucine, L -isoleucine and L -norvaline
Examples and characterization of new maleates of amino acids
Simple and efficient modifications of well known techniques for reliable growth of high-quality crystals of small bioorganic molecules
Procedure for reliable obtaining crystals of small organic molecules
Contributors
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