What is it about?
This is a review of papers on membrane fusion, that looks to see if there is a link between experimental design and reported function (inhibitory, activating or both) for an important mammalian regulatory protein Munc18.
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Why is it important?
The review suggests that removing the C-terminal membrane anchor from Syntaxin - the membrane protein partner of Munc18 - may influence the outcome of the experiment.
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This page is a summary of: Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly, IUCrJ, October 2014, International Union of Crystallography,
DOI: 10.1107/s2052252514020727.
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