What is it about?
This work is about solving the structure of an anticancer drug Bisantrene or Orange Crush using X-ray Crystallography.
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Why is it important?
The X-ray structure of this molecule is important for understanding its biological activity as anticancer agent as well as its solubility and dissolution properties in formulation.
Perspectives
It is interesting that this molecules can form cis- and trans-arrangement of the side chains. The molecules form acetate and chloride salts.
Professor Teruna J Siahaan
University of Kansas
Read the Original
This page is a summary of: 9,10-Anthracenedicarbaldehyde bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] acetic acid hydrochloric acid trihydrate salt (bisantrene), Acta Crystallographica Section C Crystal Structure Communications, February 1986, International Union of Crystallography,
DOI: 10.1107/s010827018609683x.
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