What is it about?
SARS-CoV-2 attaches to human cells through tight contacts established by a viral component, known as spike and a human protein called ACE2. We have studied a SARS-CoV-2 single mutant that confers the SARS-CoV-2 spike a stronger adherence to ACE2 and provide in this report the molecular reasons for this enhanced affinity.
Featured Image
Photo by Sandy Millar on Unsplash
Why is it important?
Our studies contribute to a deeper understanding on the impact of a relevant mutation present in current SARS-CoV-2 circulating variants and which might lead to stronger host-pathogen interactions.
Perspectives
Read the Original
This page is a summary of: Structural bases for the higher adherence to ACE2 conferred by the SARS-CoV-2 spike Q498Y substitution, Acta Crystallographica Section D Structural Biology, August 2022, International Union of Crystallography,
DOI: 10.1107/s2059798322007677.
You can read the full text:
Contributors
The following have contributed to this page