What is it about?
Plants make a variety of chemicals to protect themselves from microbes. We analyzed the three dimensional shapes of proteins involved in converting benzoic acid derived compounds into chemicals that apples and other plants use to protect themselves from bacteria and fungi.
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Why is it important?
Our findings show that the active sites of plant polyketide synthases involved in converting benzoic acid derived chemicals into antimicrobial metabolites have an unusual shape. Additionally, these plant polyketide synthases have amino acids in their active sites that interact favorably with benzoyl-CoA. The unique features of these benzoic acid-specific plant polyketide synthases help us further our understanding of the interplay between structure and function in plant polyketide synthases.
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This page is a summary of: Molecular architectures of benzoic acid-specific type III polyketide synthases, Acta Crystallographica Section D Structural Biology, November 2017, International Union of Crystallography, DOI: 10.1107/s2059798317016618.
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This article is published as Stewart, Charles, Kate Woods, Greg Macias, Andrew C. Allan, Roger P. Hellens, and Joseph P. Noel. "Molecular architectures of benzoic acid-specific type III polyketide synthases." Acta Crystallographica Section D: Structural Biology 73, no. 12 (2017): 1007-1019. DOI: 10.1107/ S2059798317016618. Posted with permission.
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