An overview of comparative modelling and resources dedicated to large-scale modelling of genome sequences

  • Su Datt Lam, Sayoni Das, Ian Sillitoe, Christine Orengo
  • Acta Crystallographica Section D Structural Biology, July 2017, International Union of Crystallography
  • DOI: 10.1107/s2059798317008920

What is it about?

Computational modelling of proteins has been a major catalyst in structural biology. Bioinformatics groups have exploited the repositories of known structures to predict high-quality structural models with high efficiency at low cost. This article provides an overview of comparative modelling, reviews recent developments and describes resources dedicated to large-scale comparative modelling of genome sequences. The value of subclustering protein domain superfamilies to guide the template-selection process is investigated. Some recent cases in which structural modelling has aided experimental work to determine very large macromolecular complexes are also cited.

Why is it important?

This paper reviewed some of the recent developments in computational structural modelling field.

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