What is it about?
Cocrystal formation can improve drug performace, for example its water solubility. We tried to understand why certain cocrystals are favoured and what is governing their formation. We have shown that in the case of apremilast, an anti-psoriatic drug this formation is govern by entropy.
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Why is it important?
Understanding why and how cocrystals are formed will hopefully help us to design new, improved forms of drugs with poor bioavailability.
Read the Original
This page is a summary of: Understanding the formation of apremilast cocrystals, Acta Crystallographica Section B Structural Science Crystal Engineering and Materials, September 2019, International Union of Crystallography, DOI: 10.1107/s205252061900917x.
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