What is it about?
The SARS-CoV-2 main protease (Mpro) is a key enzyme in coronavirus replication, making it an important target for COVID-19 antiviral drug design. In this publication we show the atomic structure of Mpro at temperatures ranging from cryogenic to physiological, exploring how correlated structural movements may inform function.
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Why is it important?
Our data reveal a network of subtle but provocative temperature-dependent conformational diversity spanning several functionally relevant sites throughout Mpro. These findings are significant as they may motivate the design of antiviral drugs that target Mpro in regions other than the active site, which importantly could aid in preparation for future coronavirus pandemics.
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This page is a summary of: The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (Mpro), IUCrJ, August 2022, International Union of Crystallography,
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