A226V mutation in virus during the 2007 chikungunya outbreak in Kerala, India

  • N. P. Kumar, R. Joseph, T. Kamaraj, P. Jambulingam
  • Journal of General Virology, August 2008, Society for General Microbiology
  • DOI: 10.1099/vir.0.83628-0

A crucial Envelope gene mutation in Chikungunya Virus, leading to disease outbreak in Kerala, India.

What is it about?

A crucial mutation in the Envelope gene of the Chikungunya virus occurred in 2007 in Kerala, India. This mutation enabled the virus to adapt to Aedes albopictus, the predominant Aedes species in the region as its major vector species. This micro-evolutionary event would have been instrumental in causing the widespread outbreak of Chikungunya fever in Kerala state during 2007-2008.

Why is it important?

This study reports a crucial and epidemiologically significant evolutionary adaptation which occurred in CHIKV, during its recent epidemic in India

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The following have contributed to this page: Dr. N Pradeep Kumar