What is it about?
There are two replication proteins repA and repB of the Mycobacterial plasmid of the strain M. fortuitum. The study describes the interaction between two plasmid replication proteins in Mycobacteria. The recruitment of the two proteins to the origin of the plasmid and its subsequent opening has a mechanism similar to the interaction between sigma factor and RNA polymerase during the process of transcription.
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Why is it important?
The process of origin opening in case of DNA replication is not very well understood. This study highlights one of the basic mechanisms how a minimum of two proteins can initiate the process of DNA replication in case of plasmids.
Perspectives
Plasmids are the simplest self-replicating DNA molecules and are the basic models to study DNA replications. The finding will highlight the essential steps of the process of replication and will give opportunities to design better therapeutics.
sourabh samaddar
Bose Institute
Read the Original
This page is a summary of: Mutual interaction enables the mycobacterial plasmid pAL5000 origin binding protein RepB to recruit RepA, the plasmid replicase, to the origin, Microbiology, April 2017, Society for General Microbiology,
DOI: 10.1099/mic.0.000447.
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