synaptic plasticity changes activation routes in brain networks

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Why is it important?

Our studies using fMRI of synaptic potentiation in the hippocampus have revealed both short- and long-term synaptic modulation of activity propagation. We show up-regulation of fMRI signals in neocortical and mesolimbic sites following LTP of the perforant pathway. This suggests that the impact of local synaptic plasticity may not be restricted to the synaptic relay at which it is induced, as it is so usually studied, but may open up the regulation of activity propagation at the systems level.