Disentangling protein-silica interactions

L. Giussani, G. Tabacchi, E. Gianotti, S. Coluccia, E. Fois
  • Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, February 2012, Royal Society Publishing
  • DOI: 10.1098/rsta.2011.0267

Adhesion of proteins on silica surfaces

What is it about?

Adhesion on silica surfaces can stabilize proteins under conditions different from the physiological ones. Using computer simulations we studied the behaviour of pepsin - an important digestive enzyme - inside a water droplet. The enzyme-containing droplet was put in contact with a flat silica surface.

Why is it important?

Water and the charge-balancing ions are responsible of the surface-protein adhesion.

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The following have contributed to this page: Gloria Tabacchi