What is it about?
Adhesion on silica surfaces can stabilize proteins under conditions different from the physiological ones. Using computer simulations we studied the behaviour of pepsin - an important digestive enzyme - inside a water droplet. The enzyme-containing droplet was put in contact with a flat silica surface.
Why is it important?
For the first time, we showed that water and the charge-balancing ions are responsible of the surface-protein adhesion.
Read the Original
This page is a summary of: Disentangling protein-silica interactions, Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, February 2012, Royal Society Publishing, DOI: 10.1098/rsta.2011.0267.
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