What is it about?
This paper proposes an energy-based mathematical modelling technique (originally developed by engineers) to build modular models of the complex biochemical systems within the human body.
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Why is it important?
Methods that allow modular models to be constructed while ensuring fundamental physical laws are obeyed will help to improve reusability and extensibility of mathematical models in biology.
Perspectives
There is increasing scientific and medical interest in understanding how the human body generates, transports and uses energy in sickness and in health. Mathematical models based on the underlying science can be used within computers to test hypotheses and to suggest new experiments.
Professor Peter J Gawthrop
University of Melbourne
Read the Original
This page is a summary of: Energy-based analysis of biochemical cycles using bond graphs, Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences, September 2014, Royal Society Publishing,
DOI: 10.1098/rspa.2014.0459.
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