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Why is it important?
Migration of cells across the surface of the eye, the cornea, is essential for replacing those that fall off when we blink or rub our eyes. Failure of cell migration leads to corneal disease that can lead to blindness. The discovery that PCP genes control the process gives new insight into possible therapies for corneal disease. It is also the first time that PCP pathways have been proven to direct normal cell migration in any adult vertebrate system.
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The core planar cell polarity gene,
Vangl2
, directs adult corneal epithelial cell alignment and migration
, Royal Society Open Science, October 2016, Royal Society Publishing,
DOI: 10.1098/rsos.160658.
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