What is it about?
Alike many cellular activities and phenotypes, the reproduction of the genetic material (DNA) is under the control of cellular metabolism. We propose in our review a general model for this and a biological function.
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Why is it important?
Based on mechanistic data, we propose that the metabolic control of DNA is geared by systems orchestrating metabolome homeostasis.
Perspectives
Find which metabolites control DNA synthesis and whether changes in these pools impact genetic stability and open the route to tumorigenesis .
Dr Laurent Janniere
Genopole, CNRS, UEVE, Paris-Saclay
Read the Original
This page is a summary of: The metabolic control of DNA replication: mechanism and function, Open Biology, August 2023, Royal Society Publishing,
DOI: 10.1098/rsob.230220.
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