What is it about?
About 1% of women suffer from recurrent pregnancy losses. The underlying genetics is ill-known. In this paper we report on variants of the FOXD1 gene that are associated with some cases of this disease.
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Why is it important?
Sequencing of FOXD1 in women affected by Recurrent Pregnancy Losses could allow to diagnose the cause and to propose therapeutic solutions.
Perspectives
In this study, we started from a mouse genetic work where we tried to find associations between embryonic resorbtion (the equivalent of human miscarriage) and gene variants. This led us to Foxd1, which we sequenced on a large sample of women affected with Recurrent Pregnancy Losses and control women. This is an illustration on how basic science on animal models may shed light on complex human diseases
Dr Daniel Vaiman
INSERM U106
Read the Original
This page is a summary of:
Association of
FOXD1
variants with adverse pregnancy outcomes in mice and humans
, Open Biology, October 2016, Royal Society Publishing,
DOI: 10.1098/rsob.160109.
You can read the full text:
Resources
Miscarriage gene: Mutations to a specific gene ‘increase your risk of suffering a miscarriage’
Article in The Sun Online referring to the paper
Is this the miscarriage gene? Women who have a specific mutation are at 'higher risk of losing their baby'
Article in the Mail Online referring to the paper
Possible miscarriage gene found: study
Blog in Medical Xpress about the paper
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