What is it about?
We want to understand the molecular biology of some genes, like the toxin-antitoxin ones, of the pathogenic bacteria Streptococcus pneumoniae (the pneumococcus) and the processes involved in the transfer of DNA (and antibiotic-resistance spread) among bacteria
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Why is it important?
Pneumococcal pneumonia is a deadly infection that causes around 1.5 million deaths per year, being especially lethal for elder people and children below 5 years old.
Perspectives
In this particular publication we addressed the question whether a genetic island which does not have apparent selective advantage can be transferred among streptococci by means of a protein encoded by the element. Further, we developed a novel method to determine specific cleavage sites in DNA molecules.
Prof Manuel Espinosa
Centro de Investigaciones Biologicas, CSIC
Read the Original
This page is a summary of: Streptococcal group B integrative and mobilizable element IMESag-rpsIencodes a functional relaxase involved in its transfer, Open Biology, October 2016, Royal Society Publishing,
DOI: 10.1098/rsob.160084.
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