What is it about?
Cancer is a disease regulated by the underlying gene networks. We constructed a cancer gene network based on the experimental evidences. We uncovered the underlying landscape and kinetic paths. Tri-stable basins characterize normal, cancer and apoptosis states. We suggested two mechanisms of cancerization: 1. Through the changes on landscape topography from changes in regulation strengths. 2. Through the stochastic fluctuations over the critical barrier at fixed landscape. Kinetic paths quanti
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Why is it important?
Cancer is a disease regulated by the underlying gene networks. We constructed a cancer gene network based on the experimental evidences. We uncovered the underlying landscape and kinetic paths. Tri-stable basins characterize normal, cancer and apoptosis states. We suggested two mechanisms of cancerization: 1. Through the changes on landscape topography from changes in regulation strengths. 2. Through the stochastic fluctuations over the critical barrier at fixed landscape. Kinetic paths quanti
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This page is a summary of: Quantifying the underlying landscape and paths of cancer, Journal of The Royal Society Interface, September 2014, Royal Society Publishing,
DOI: 10.1098/rsif.2014.0774.
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