Association of FOXD1 variants with adverse pregnancy outcomes in mice and humans

  • Paul Laissue, Besma Lakhal, Magalie Vatin, Frank Batista, Gaëtan Burgio, Eric Mercier, Esther Dos Santos, Christophe Buffat, Diana Carolina Sierra-Diaz, Gilles Renault, Xavier Montagutelli, Jane Salmon, Philippe Monget, Reiner A. Veitia, Céline Méhats, Marc Fellous, Jean-Christophe Gris, Julie Cocquet, Daniel Vaiman
  • Open Biology, October 2016, Royal Society Publishing
  • DOI: 10.1098/rsob.160109

FOXD1 mutations increase the risk of recurrent pregnancy loss.

What is it about?

About 1% of women suffer from recurrent pregnancy losses. The underlying genetics is ill-known. In this paper we report on variants of the FOXD1 gene that are associated with some cases of this disease.

Why is it important?

Sequencing of FOXD1 in women affected by Recurrent Pregnancy Losses could allow to diagnose the cause and to propose therapeutic solutions.

Perspectives

Dr Daniel Vaiman
INSERM U106

In this study, we started from a mouse genetic work where we tried to find associations between embryonic resorbtion (the equivalent of human miscarriage) and gene variants. This led us to Foxd1, which we sequenced on a large sample of women affected with Recurrent Pregnancy Losses and control women. This is an illustration on how basic science on animal models may shed light on complex human diseases

Read Publication

http://dx.doi.org/10.1098/rsob.160109

The following have contributed to this page: Dr Daniel Vaiman