The anti HIV drug inhibits the α7-Nicotinic acetylcholine receptor
What is it about?
Finding new uses for old drugs is as much about continuing to try compounds and luck as anything else. But we can more quickly find them with computational approaches. This study was focused on finding positive allosteric modulators but we found that at higher concentrations the protease inhibitor Indinavir could act as an inhibitor of the receptor.
Why is it important?
We used a known drug to build the positive allosteric modulator model. We screened known drugs and picked a few compounds to test. The focus of this study was interesting because of the association with HIV associated dementia
The following have contributed to this page: Dr Sean Ekins