What is it about?
Finding new uses for old drugs is as much about continuing to try compounds and luck as anything else. But we can more quickly find them with computational approaches. This study was focused on finding positive allosteric modulators but we found that at higher concentrations the protease inhibitor Indinavir could act as an inhibitor of the receptor.
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Why is it important?
We used a known drug to build the positive allosteric modulator model. We screened known drugs and picked a few compounds to test. The focus of this study was interesting because of the association with HIV associated dementia
Perspectives
A great example of using computational approaches to understand potential clinical implications of drugs - in this case antiacetylcholinergic effects.
Dr Sean Ekins
Collaborations in Chemistry
Read the Original
This page is a summary of: α7-Nicotinic acetylcholine receptor inhibition by indinavir, AIDS, May 2017, Wolters Kluwer Health,
DOI: 10.1097/qad.0000000000001488.
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