α7-Nicotinic acetylcholine receptor inhibition by indinavir

  • implications for cognitive dysfunction in treated HIV disease
  • Sean Ekins, Paul Mathews, Erin K. Saito, Natalie Diaz, David Naylor, Julia Chung, Aaron M. McMurtray
  • AIDS, May 2017, Wolters Kluwer Health
  • DOI: 10.1097/qad.0000000000001488

The anti HIV drug inhibits the α7-Nicotinic acetylcholine receptor

What is it about?

Finding new uses for old drugs is as much about continuing to try compounds and luck as anything else. But we can more quickly find them with computational approaches. This study was focused on finding positive allosteric modulators but we found that at higher concentrations the protease inhibitor Indinavir could act as an inhibitor of the receptor.

Why is it important?

We used a known drug to build the positive allosteric modulator model. We screened known drugs and picked a few compounds to test. The focus of this study was interesting because of the association with HIV associated dementia

Perspectives

Dr Sean Ekins
Collaborations in Chemistry

A great example of using computational approaches to understand potential clinical implications of drugs - in this case antiacetylcholinergic effects.

Read Publication

http://dx.doi.org/10.1097/qad.0000000000001488

The following have contributed to this page: Dr Sean Ekins