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This study explored the effects of trans-auricular Vagus nerve stimulation (TaVNS) on stroke recovery. Seventy-eight chronic stroke patients were divided into two groups: one received real TaVNS and the other received a sham version, both followed by physical therapy. After four weeks, the group receiving real TaVNS showed significant improvements in serum Brain-Derived Neurotrophic Factors (BDNF), Interleukin-6 (IL-6), and manual dexterity, indicating enhanced neuroplasticity and reduced inflammation. However, there was no significant change in spasticity between the groups. This suggests TaVNS could be a beneficial addition to stroke rehabilitation, improving motor function and potentially influencing recovery outcomes.

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This page is a summary of: Plasticity Biomarkers, Interleukin-6 and Motor Performance Responses to Trans-auricular Vagus Nerve Stimulation Post-Stroke: A Randomized Controlled Trial, American Journal of Physical Medicine & Rehabilitation, October 2025, Wolters Kluwer Health,
DOI: 10.1097/phm.0000000000002878.
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