What is it about?
This report characterizes JAK/STAT signaling patterns in molecularly defined subsets of MPN utilizing immunohistochemistry for pSTAT3 and pSTAT5.
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Why is it important?
It provides an additional example of the utility of phospho-protein immunohistochemistry to elucidate dysregulated signaling patterns in hematologic malignancies, confirms the utility of pSTAT5 immunohistochemistry in the evaluation of suspected MPN, and, most importantly, reveals distinct signaling patterns in JAK2 mutated, CALR mutated, and triple negative-MPN. This finding suggests that pathways other than pSTAT5 are responsible for the morphologic and clinical similarities in MPNs with divergent profiles.
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This page is a summary of: pSTAT3/pSTAT5 Signaling Patterns in Molecularly Defined Subsets of Myeloproliferative Neoplasms, Applied Immunohistochemistry & Molecular Morphology, June 2016, Wolters Kluwer Health,
DOI: 10.1097/pai.0000000000000391.
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