What is it about?
Corticosteroid appears associated with shortened hospital stay for anaphylaxis in hospital-admitted children but whether ED-discharged patients will benefit is uncertain. Unnecessary routine corticosteroid use can have adverse effects.
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Why is it important?
Pilot blinded randomized trial of children 3 months to 14 years presenting with anaphylaxis, comparing ED predischarge 0.3 mg/kg oral dexamethasone solution, 1 mg/mL, maximum 10 mg, or an equal volume of blinded identical placebo, to determine if revisit for recurrence to any health care facility within 7 days would be reduced.
Perspectives
Uncommon recurrence and high number needed to treat after ED anaphylaxis treatment suggests against routine ED predischarge corticosteroid without a clinical rationale
Dr Khalid Mohamed Alansari
Hamad Medical corporation
Read the Original
This page is a summary of: Randomized blinded pilot trial of corticosteroid after mild-moderate anaphylaxis to prevent recurrence, Medicine, August 2025, Wolters Kluwer Health,
DOI: 10.1097/md.0000000000043600.
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