Predictive and Prognostic Factors of Breast Carcinoma
What is it about?
Various predictive and prognostic factors could affect breast carcinoma behavior, but to date no definitive correlation has been established between them and breast carcinoma subtypes. The present study was conducted to examine the interrelationships of these predictive and prognostic factors as well as their effects on breast carcinoma subtypes.
Why is it important?
Breast cancer patients with higher Ki67 expression showed more HER2/neu overexpression, and these cancers may be identified as aggressive tumors. Moreover, in young patients with breast carcinoma, the rates of Ki67 with overexpression of HER2/neu and p53 mutation were higher, and it is shown to be indicative of a more invasive tumor and a higher frequency of metastasis. However, p53 mutation was seen with higher tumor grades, but no significant correlation was obtained between its status and lymph node involvement, so its role in the progression of tumors remains unclear.
The following have contributed to this page: Professor shokouh Taghipour zahir, Mr Ezatollah Aalipour, and mr poorya barand