What is it about?

To evaluate the efficacy and safety of most selective serotonin reuptake inhibitor drug, escitalopram, in delaying ejaculation in patients with premature ejaculation (PE).

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Why is it important?

Premature ejaculation is the most common form of sexual dysfunction in men, affecting up to 21% of men aged 18 to 59 years in the United States.1 In general, however, the prevalence of PE is reported as being between 22% and 38% of adult male population


It seems that escitalopram provides a clear advantage in improving geometric mean IELT compared with other SSRIs. Clearly, the issue of placebo-controlled trials will remain the ultimate litmus test of treatment efficacy. Nearly all of the current pharmacotherapy for PE are palliative and do not Btreat[ or Bcure[ the problem actually. Although the therapeutic effect of a drug is seen within weeks, in minimum, alleviation of problem for a much longer time is required.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

Read the Original

This page is a summary of: Safety and Efficacy of Escitalopram in the Treatment of Premature Ejaculation, Journal of Clinical Psychopharmacology, October 2007, Wolters Kluwer Health, DOI: 10.1097/jcp.0b013e31814b98d4.
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