Deep sedation for colonoscopy in overweight patients: a comparison between Propofol alone versus Propofol and Ketamine

W Chalayonnawin, S Kongphlay, S Amornyotin
  • International Journal of Evidence-Based Healthcare, September 2012, Wolters Kluwer Health
  • DOI: 10.1097/01258363-201209000-00019

Deep sedation for colonoscopy in overweight patients: Propofol versus Propofol and Ketamine

What is it about?

The aim of this study was to evaluate and compare the clinical efficacy of propofol alone and propofol and ketamine for deep sedation for colonoscopy in overweight (BMI > 25) patients in a teaching hospital in Thailand.

Why is it important?

There were 104 overweight patients who underwent colonoscopic procedure by using deep sedation technique during the study period. After matching age, gender, ASA physical status and indications of procedure, 38 patients were sedated by using propofol alone (group P) and 42 patients were sedated with propofol and ketamine (group PK). All sedation was given by residents and anesthetic nurses directly supervised by staff anesthesiologist in the endoscopy room. There were no significant differences in patients' characteristics, sedation time, indication, anesthetic personnel, mortality rate, success rate and sedative agents used between the two groups. Sedation-related complications including hypotension in group P was significantly higher than in group PK. However, all complications were easily treated, with no adverse sequelae.


Somchai Amornyotin
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University

Deep sedation in both regimens for colonoscopy in overweight patients provided effective and safe. No serious adverse events were observed. However, the complications of propofol and ketamine used for DS had significantly lower complication than the propofol alone.

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The following have contributed to this page: Somchai Amornyotin