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What is it about?

Four-factor prothrombin complex concentrates (PCC) produce a more rapid and complete INR correction compared with 3-factor PCC in patients receiving warfarin. It is unknown if this improves clinical outcomes in the setting of intracranial hemorrhage (ICH). The objective of our study was to evaluate the efficacy of 3- and 4-factor PCC in those presenting with warfarin-associated ICH. In-hospital mortality was not improved with the use of 4- vs. 3-factor PCC in the emergent reversal of warfarin-associated ICH. The effect on secondary clinical outcomes were similarly non-significant.

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