Intravenous sedation with midazolam and fentanyl versus propofol and pethidine in colonoscopy: A prospective, randomized study

S. Amornyotin, W. Srikureja, W. Chalayonnavin, S. Kongphlay
  • European Journal of Anaesthesiology, June 2010, Wolters Kluwer Health
  • DOI: 10.1097/00003643-201006121-00117

Intravenous sedation with midazolam and fentanyl versus propofol and pethidine in colonoscopy

What is it about?

A combination of opioids and benzodiazepines or propofol is usually used to achieve sedation and analgesia during colonoscopy. Few studies have compared their efficacy. The aim of this study was to compare and evaluate the clinical efficacy of the combination of midazolam and fentanyl versus propofol and pethidine when each regimen is used as sedative agents for colonoscopy.

Why is it important?

All endoscopies were completely successfully except for 33 patients (6.4%) in group MF and 11 patients (3.3%) in group PP (p=0.019). Mean total dose of midazolam and fentanyl in group MF was 0.08 (0.05) mg/hg/hr and 0.003 (0.002) mg/kg/hr. Mean total dose of propofol and pethidine in group PP was 5.98 (2.67) mg/hg/hr and 1.74 (1.05) mg/kg/hr. Additional propofol dose in group MF was 86.97 (19.60) mg, and in group PP was 38.82 (17.64) mg (p<0.001). Procedural pain and recovery time in group MF was significantly higher than in group PP (p<0.001), but recovery score at 30 min post-procedure in group MF was significantly lower than group PP (p<0.001). Tolerability of the patient, discomfort during insertion as well as patient and endoscopist satisfaction in group MF were statistically significantly lower than for patients in group PP (p<0.001). Overall, cardiovascular and respiratory adverse events in group PP were also significantly higher than in group MF. However, these adverse events were transient and easily treated with no sequelae.

Perspectives

Somchai Amornyotin
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University

IVS in both regimens provided effective and safe for colonoscopy. No serious adverse events were observed. However, the combination of propofol and pethidine used as sedative agents for IVS had significantly higher efficacy than the combination of midazolam and fentanyl.

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http://dx.doi.org/10.1097/00003643-201006121-00117

The following have contributed to this page: Somchai Amornyotin