What is it about?
Employing targeted sequencing of genetic variants in Dopamine-β-hydroxylase gene and it's activity, we were able to identify key variants that affect enzyme activity.
Photo by National Cancer Institute on Unsplash
Why is it important?
This study which for the first time employs targeted sequencing of Dopamine-β-hydroxylase gene and activity assay in a genetically distinct North Indian population was able to identify key genetic variants that determine Dopamine-β-hydroxylase activity.This information could help in designing inhibitors that could be used in personalised medicine.
Read the Original
This page is a summary of: Deep sequencing identifies novel regulatory variants in the distal promoter region of the dopamine-β-hydroxylase gene, Pharmacogenetics and Genomics, July 2016, Wolters Kluwer Health, DOI: 10.1097/fpc.0000000000000214.
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