What is it about?

Assessment of the robustness of statistically significant outcomes from randomised control trials(RCTs) in spine surgery using Fragility Index(FI) which is a novel metric measuring the number of events upon which statistical significance of the outcome depends.

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Why is it important?

Many trials in Spine surgery were characterized by fewer outcome events along with small sample size. Fragility Index(FI) helps us identify the robustness of the results from such studies with statistically significant dichotomous outcomes.


This research gives insight into the intricacies in the interpretation of the results of the RCT despite its evidence level.

Dr Sathish Muthu
Government Hospital, Velayuthampalayam, Karur, TN, India.

Read the Original

This page is a summary of: Fragility Analysis of Statistically Significant Outcomes of Randomised Control Trials in Spine Surgery, Spine, August 2020, Wolters Kluwer Health,
DOI: 10.1097/brs.0000000000003645.
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