First identification of novel variant CYP2C9*13 in Chinese
What is it about?
SNPs in the CYP2C9 gene are determinants of the metabolic phenotype. The present study focused on a Chinese poor metabolizer of both lornoxicam and tolbutamide. By sequencing his CYP2C9 gene, we identified the poor metabolizer heterozygous for the CYP2C9*13 together with the CYP2C9*3.
Why is it important?
This novel CYP2C9*13 allele was correlated with reduced plasma clearance of drugs that are substrates for CYP2C9. Frequency analysis in 147 Chinese males indicated approximately 2% of the Chinese population carry the allele. Biopharm.
The following have contributed to this page: Dayong Si